https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Neutrophil oxidative burst capacity for peri-operative immune monitoring in trauma patients https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20061 Sat 24 Mar 2018 08:00:04 AEDT ]]> Comparison of postinjury multiple-organ failure scoring systems: Denver versus sequential organ failure assessment https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20386 15, age > 18 years, head Abbreviated Injury Scale [AIS] score < 3, survival for >48 hours). Demographics, ISS, physiologic parameters, SOFA and Denver scores, and outcome data were prospectively collected. Sensitivity/specificity and receiver operating characteristic curve were calculated for both scores. Analysis was also completed for a Day 3 postinjury SOFA and Denver score. Results: A total of 140 patients met the inclusion criteria (mean [SD] age, 47 [21] years; ISS, 30; male, 69%; mortality rate, 6%; mean [SD] ICU LOS, 9 [7] days; mean [SD] ventilation period, 6 [7] days). There was no difference in the score performance predicting mortality. Day 3 SOFA score of 4 or greater outperformed the Denver score of greater than 3 when predicting ICU LOS and ventilator days (area under the curve, 0.83 vs. 0.69, 0.86 vs. 0.73, respectively). The SOFA score was more sensitive and the Denver score was more specific when predicting mortality, ICU LOS, and ventilator days. Conclusion: Both scores had similar performance predicting mortality; however, the Day 3 SOFA score outperforms the Denver score when predicting ICU LOS and ventilator days. Either score could be superior based on whether one is seeking to optimize specificity or sensitivity. It is important to note that these findings are in a non–head-injured population and that there are practical difficulties using the SOFA in head-injured patients.]]> Sat 24 Mar 2018 07:58:08 AEDT ]]>